Open AccessEthionamide: Unusual Cause of Hypothyroidism
Author(s) -
Ajay Raj Mallela,
Rohini Koya,
Shivashankara Kaniyoor Nagari,
Aswini Kumar Mohapatra
Publication year - 2015
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2015/13531.6331
Subject(s) - ethionamide , medicine , pediatrics , tuberculosis , regimen , adverse effect , etiology , incidence (geometry) , pharmacotherapy , intensive care medicine , ethambutol , mycobacterium tuberculosis , pathology , physics , optics
Multidrug-Resistant tuberculosis (MDR TB) is major health hazard to the people living in developing countries. As incidence rate of MDR TB has gone up, its therapy has become crucial. MDR TB therapy is known to cause multiple adverse effects however the data related to them is minimal. Hypothyroidism is one of the important adverse effects which usually manifests with vague symptoms and is frequently missed. We present a case of 24-year-old woman who was diagnosed to have MDR TB and started on ethionamide based regimen for same. After 6 months of therapy the patient had clinical symptoms suggestive of hypothyroidism, laboratory investigations confirmed it. As ethionamide is an integral component of MDR TB therapy it was continued and thyroxine replacement therapy was given with which she improved. Hypothyroidism completely resolved after 2 months of stoppage of MDR TB therapy suggesting the reversible aetiology of ethionamide.