Open AccessOPN –Revisited
Author(s) -
Vijayanirmala Subramani
Publication year - 2015
Publication title -
journal of clinical and diagnostic research
Language(s) - Uncategorized
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2015/12872.6111
Subject(s) - osteopontin , angiogenesis , extracellular matrix , metastasis , pathology , inflammation , cancer research , wound healing , biology , epithelium , microbiology and biotechnology , medicine , immunology , cancer
Osteopontin (OPN), a matrix extracellular glyco-phosphoprotein is found in various tissues such as epithelium lined tissues, kidney, bone and teeth .It is also detected in all body fluids including blood and breast milk. OPN plays role in a number of physiological and pathologic events such as cell adhesion, migration and cell survival, angiogenesis, apoptosis, inflammation and wound healing. This review summarizes the current data of the biological activities of OPN in the development of tumour, its progression and metastasis.