Open AccessThe Prognostic Significance of Neuroendocrine Differentiation in Colorectal Carcinomas: Our Experience
Author(s) -
Pooja K Suresh,
Kausalya Kumari Sahu,
Radha R. Pai,
H Sridevi,
Kirthinath Ballal,
Binit Kumar Khandelia,
Jessica Minal,
Rajendra Annappa
Publication year - 2015
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2015/12800.6854
Subject(s) - neuroendocrine differentiation , chromogranin a , synaptophysin , immunohistochemistry , stage (stratigraphy) , neuroendocrine tumors , pathology , clinical significance , medicine , gastroenterology , biology , cancer , prostate cancer , paleontology
Neuroendocrine differentiation in colorectal carcinomas, detected using immunohistochemistry and ultrastructural techniques, has been studied as a prognostic marker for invention of targeted therapy. There are a few studies done on this aspect which have shown conflicting results ranging from poor prognosis to no prognostic significance.