Open AccessExpression of Osteopontin in Oral Squamous Cell Carcinoma and its Surgical Margins-An Immunohistochemical Study
Author(s) -
Vijayanirmala Subramani,
Malathi Narasimhan,
Muthukumar Thiyagarajan,
Balu David Munuswamy,
Logeswari Jayamani
Publication year - 2015
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2015/12777.6836
Subject(s) - osteopontin , immunohistochemistry , medicine , pathology , surgical margin , cancer , radiation therapy , carcinoma , basal cell , surgical pathology , oncology
Despite the advances in the treatment modalities offered for oral squamous cell carcinoma. The recurrence rate of it still remains quite high. Early detection of recurrence will improve the outcome and the survival of the patient. Osteopontin, a transformation-related phosphorylated protein in epithelial cells has been closely related with tumourigenesis. This study was undertaken to explore the potential of OPN as a tumour marker of recurrence in OSCC.