Open AccessProliferating Cell Nuclear Antigen in Premalignancy and Oral Squamous Cell Carcinoma
Author(s) -
Chandrashekar Poosarla,
Maya Ramesh,
Maya Ramesh,
Swetha Gudiseva,
Sadhishkumar Balakrishnan,
Murali Sundar
Publication year - 2015
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2015/12645.6094
Subject(s) - proliferating cell nuclear antigen , pathology , dysplasia , medicine , oral mucosa , cancer , proliferation index , cell growth , carcinoma , cell , antigen , epithelial dysplasia , immunohistochemistry , biology , immunology , genetics
Cancer has multifactorial aetiology and is a multistep process involving initiation, promotion and tumour progression. Cellular proliferation is one of the important indicators for the biologic aggressiveness of a malignant lesion. The dysregulated proliferation may be a significant change to determine the potential prognosis of various malignant tumours.