Open AccessAssociation of Angiotensin Converting Enzyme Gene Insertion / Deletion Polymorphism with Risk of Ischemic Heart Disease in A Population of Smokers in Southern India
Author(s) -
Sandhya Mangalore,
Uppala Satyanarayana,
Basalingappa Dr,
Badeti,
Geeta Mitta,
Sujata Mohanty,
P Subhadra,
Qurratulain Hasan
Publication year - 2015
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2015/12634.5852
Subject(s) - medicine , genotype , angiotensin converting enzyme , allele , myocardial infarction , disease , population , allele frequency , gastroenterology , gene , genetics , biology , blood pressure , environmental health
Ischemic heart disease (IHD) remains a major public health problem nationally and internationally. Smoking is a major risk factor for IHD.The deletion (D) allele of the angiotensin converting enzyme (ACE) gene polymorphism has been associated with hypertension, ischemic stroke and myocardial infarction. The present study was carried out to determine the association of the ACE gene insertion/deletion (I/D) polymorphism in IHD patients with and without smoking.