Open AccessPrimary Diffuse Large B-cell Lymphoma Arising in the Tongue Accompanied by Ataxia-telangiectasia: A Case Report
Author(s) -
Hirofumi Tomioka,
Ayano Kaneoya,
Yumi Mochizuki,
Hiroyuki Harada
Publication year - 2015
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2015/12121.6107
Subject(s) - ataxia telangiectasia , medicine , rituximab , lymphoma , cyclophosphamide , prednisolone , vincristine , telangiectasia , tongue , pathology , immunodeficiency , dermatology , ataxia , chemotherapy , gastroenterology , surgery , immunology , dna , genetics , immune system , dna damage , biology , psychiatry
Ataxia-telangiectasia (AT) is a rare autosomal recessive disorder that is characterized by progressive cerebellar ataxia, telangiectasia, immunodeficiency, and a predisposition to leukemia/lymphoma. Here we report a rare case of lymphoma of the tongue accompanied by AT. Tumour extirpation was performed and diffuse large B-cell lymphoma was diagnosed following pathologic examination. A whole-body survey showed no other enlarged lymph nodes or tumour. The female patient then received a modified dosage of COPAD (cyclophosphamide, vinblastine, pirarubicin, and prednisolone) plus rituximab to avoid severe complications. As of follow-up after 3 years and 5 months, she remains in complete remission. Patients showing AT need careful surveillance and long-term continuous follow-up.