Open AccessA Comparative Study of the Clinical Efficacy and Safety of Lorazepam and Chlordiazepoxide in Alcohol Dependence Syndrome
Author(s) -
Ranjani Ramanujam
Publication year - 2015
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2015/11887.5678
Subject(s) - chlordiazepoxide , lorazepam , medicine , diazepam , alcohol , alcohol withdrawal syndrome , alcohol dependence , anesthesia , randomization , randomized controlled trial , chemistry , biochemistry
Currently, benzodiazepines are the preferred drugs in the management of alcohol withdrawal symptoms. Chlordiazepoxide and diazepam, the most frequently used drugs have a long duration of action and are converted to active metabolites in the liver, while lorazepam is shorter acting, with no active metabolites.