Open AccessEvidence of Paternal N5, N10 - Methylenetetrahydrofolate Reductase (MTHFR) C677T Gene Polymorphism in Couples with Recurrent Spontaneous Abortions (RSAs) in Kolar District- A South West of India
Author(s) -
Shiny Vanilla,
C. D. Dayanand,
Pushpa Kotur,
Moideen A Kutty,
Pradeep Kumar Vegi
Publication year - 2015
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2015/10856.5579
Subject(s) - methylenetetrahydrofolate reductase , genotype , medicine , pregnancy , reductase , restriction fragment length polymorphism , gene mutation , polymorphism (computer science) , abortion , genetics , gastroenterology , gynecology , biology , mutation , gene , enzyme , biochemistry
Recurrent spontaneous abortion (RSA) is a multifactorial clinical obstetrics complication commonly occurring in pregnancy. Many research studies have noted the mutations such as C677T in N5, N10 - Methylenetetrahydrofolate reductase (MTHFR)gene which is regarded as RSA risk factor. This study was carried out to determine the occurrence of frequency of C677T of the MTHFR gene mutations with RSA.