Open AccessAntidepressant Effect of Ketamine in Sub Anaesthetic Doses in Male Albino Mice
Author(s) -
Lourdu Jafrin Antony,
Venkata Naveen Kumar Paruchuri,
Ramchandar Ramanan
Publication year - 2014
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2014/9679.4445
Subject(s) - ketamine , imipramine , antidepressant , pharmacology , behavioural despair test , serotonergic , tricyclic antidepressant , animal models of depression , medicine , anesthesia , serotonin , receptor , hippocampus , alternative medicine , pathology
Depression is the most common mental disorder in community settings, and is a major cause of disability across the world. Antidepressants such as SSRI (Selective Serotonin Reuptake Inhibitor) and TCA (Tricyclic antidepressants) are used. These drugs affect the adrenergic and serotonergic pathways. These drugs have an unfavorable side effect profile, take longer time to act and are not very effective in resistant cases. Alternate pathways involving the glutamate receptors have also been linked with depression, hence Ketamine an NMDA antagonist was evaluated for the antidepressant effect.