Open AccessImmunohistochemical expression of Type IV Collagen and Autocrine Motility Factor Receptor in Odontogenic Tumours
Author(s) -
Harshaminder Kaur Grewal,
Sneha Sethi
Publication year - 2014
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2014/9405.4951
Subject(s) - autocrine signalling , biology , ameloblastoma , pathology , immunohistochemistry , keratocyst , cancer research , receptor , medicine , immunology , cyst , anatomy , maxilla , biochemistry
Autocrine motility factor receptor (AMFR) is a tumour motility stimulating protein secreted by tumour cells. The protein encoded by this gene is a glycosylated transmembrane protein and a receptor for autocrine motility factor. It has been known to play a role in progression of neoplastic lesions. Basement membranes are specialized extracellular matrices that serve as structural barriers as well as substrates for cellular interactions. The network of type IV collagen is thought to define the scaffold integrating other components such as laminins and perlecan into highly organized supramolecular architecture. The aim of this study was to determine and evaluate the immunohistochemical expression of Type IV Collagen and Autocrine motility factor receptor in odontogenic lesions.