Open AccessComparative Study of Genotoxicity in Different Tobacco Related Habits using Micronucleus Assay in Exfoliated Buccal Epithelial Cells
Author(s) -
Yadavalli Guruprasad,
Maji Jose,
Kartikay Saxena,
Vishnudas Prabhu
Publication year - 2014
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2014/8733.4357
Subject(s) - micronucleus test , buccal swab , genotoxicity , micronucleus , smokeless tobacco , buccal administration , giemsa stain , oral mucosa , physiology , chewing tobacco , medicine , clastogen , tobacco smoke , biology , pathology , toxicology , cancer , environmental health , genetics , dentistry , tobacco use , population , toxicity
Oral cancer is one of the most debilitating diseases afflicting mankind. Consumption of tobacco in various forms constitutes one of the most important etiological factors in initiation of oral cancer. When the focus of today's research is to determine early genotoxic changes in human cells, micronucleus (MN) assay provides a simple, yet reliable indicator of genotoxic damage.