Open AccessHerpes Gestationis after Ovodonation: Is Placenta the only Target of the Immune Reaction?
Author(s) -
Isabella Piva,
Giuseppe Lo Monte,
Angela Graziano,
Roberto Marci
Publication year - 2014
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2014/8727.5103
Subject(s) - gestation , pregnancy , medicine , placenta , obstetrics , immune system , pathogenesis , disease , hormone , autoimmune disease , fetus , gynecology , immunology , endocrinology , biology , genetics
Herpes Gestationis (HG) is an autoimmune disorder that rarely complicates pregnancy. Its pathogenesis has not been clarified yet, as it derives from a complex interplay between immunologic, genetic, and hormonal factors. We present a case of HG occurring in a surrogate mother whose pregnancy was achieved via egg donation and in vitro fertilisation (IVF). The disease appeared at 26 weeks and 6 days of gestation and subsequently worsened despite the administration of oral and topic corticosteroids. A healthy baby was delivered at 35 weeks and 2 days of gestation by elective cesarean section and the clinical manifestations resolved in the postpartum period.