Open AccessNeuromyelitis Optica with NMO-IgG/Anti-AQP4 Antibody Positive: First Case Reported from Uttarakhand India
Author(s) -
Manish Mittal,
Garima Mittal
Publication year - 2014
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2014/8577.4625
Subject(s) - neuromyelitis optica , transverse myelitis , optic neuritis , medicine , multiple sclerosis , pathology , optic nerve , myelitis , demyelinating disease , autoantibody , spinal cord , aquaporin 4 , hyperintensity , central nervous system , antibody , magnetic resonance imaging , immunology , ophthalmology , radiology , psychiatry
Neuromyelitis optica (also known as Devic's disease) is an idiopathic, severe, demyelinating disease of the central nervous system that preferentially affects the optic nerve and spinal cord. The presence of a highly specific serum autoantibody marker (NMO-IgG) further differentiates neuromyelitis optica from multiple sclerosis and has helped to define a neuromyelitis optica spectrum of disorders. We present a case of 37-year-old man who has initially presented with transverse myelitis from which he recovered partially after treatment but later presented with bilateral optic neuritis. MRI brain revealed hyperintensity in bilateral optic nerves, periventricular area and also in the thalamic region. Diagnosis was confirmed by positive NMO - IgG/anti-AQP4 antibody.