Open AccessPossible Role of Curcumin as ection an Efflux Pump Inhibitor in Multi Drug Resistant Clinical Isolates of Pseudomonas aeruginosa
Author(s) -
Nidhi Negi,
Pradyot Prakash,
Mohan L. Gupta,
Tribhuban Mohan Mohapatra
Publication year - 2014
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2014/8329.4965
Subject(s) - efflux , curcumin , pseudomonas aeruginosa , antimicrobial , multiple drug resistance , pharmacology , microbiology and biotechnology , minimum inhibitory concentration , drug resistance , drug , in vivo , chemistry , bacteria , biology , biochemistry , genetics
Multidrug resistant non-fermenters are continuously increasing in hospital and ICU settings. One of the mechanisms of developing drug resistance is possession of efflux pump through which bacteria extrude antimicrobial agents and other toxic substances. If these efflux channels are blocked or inhibited, increased drug concentration can be achieved in a bacterial cell with optimal drug dose. Present study was aimed to investigate role of curcumin as efflux pump inhibitor (EPI) and to compare its activity with a known EPI like phe-arg-beta-naphthylamide (PAβN).