Open AccessEffect of Smoking on Metalloproteinases (MMPs) Activity in Patients with Acute Myocardial Infarction (AMI)
Author(s) -
Sreekanth K Sivaraman,
Geevar Zachariah,
P T Annamala
Publication year - 2014
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2014/7052.3998
Subject(s) - matrix metalloproteinase , medicine , myocardial infarction , mmp2 , mmp9 , pathogenesis , cardiology , gastroenterology , chemistry , biochemistry , downregulation and upregulation , cancer , gene , metastasis
Many risk factors are involved in the course and pathogenesis of Acute Myocardial Infarction (AMI). Smoking can significantly increase the AMI mortality and morbidity. Matrix metalloproteinases (MMPs), a class of Zn containing enzymes, are involved in the erosion of the fibrous cap and rupture of the plaque which leads to AMI.