Open AccessA Study of Autoimmune Polyglandular Syndrome (APS) in Patients with Type1 Diabetes Mellitus Followed up at A Teritiary Care Hospital
Author(s) -
Shaheen Shaikh,
Ismail M Haji,
Parveen Doddamani,
Md. Habibur Rahman
Publication year - 2014
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2014/7013.4011
Subject(s) - medicine , vitiligo , type 1 diabetes , diabetes mellitus , adrenal crisis , pediatrics , autoantibody , disease , medical record , adrenal insufficiency , autoimmune disease , immunology , endocrinology , antibody
Type1 diabetes mellitus (T1DM) results from auto- immune destruction of insulin-producing β cells and is characterized by the presence of insulitis and β-cell autoantibodies. Up to one third of patients develop an autoimmune polyglandular syndrome (APS). Presence of other autoimmune disorders in patients with T1DM has been associated with increased morbidity and mortality. Hypoglycemia resulting from concurrent hypothyroidism or adrenal crisis can be dangerous; starting replacement therapy for hypothyroidism may result in adrenal crisis if background hypocortisolism is not recognized. Early detection of antibodies and latent organ-specific dysfunction is advocated to alert physicians to take appropriate action in order to prevent full-blown disease.