Open AccessOrigin of Ameloblastoma From Basal Cells of the Oral Epithelium- Establishing the Relation Using Neuroectodermal Markers
Author(s) -
S Suneela,
TV Narayan,
Balasundari Shreedhar,
Leeky Mohanty,
Sadhana Shenoy,
Uma Swaminathan
Publication year - 2014
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2014/6740.5026
Subject(s) - cd99 , synaptophysin , pathology , ameloblastoma , biology , basal (medicine) , epithelium , immunohistochemistry , enolase , anatomy , medicine , endocrinology , vimentin , maxilla , insulin
Basal cell layer of the oral epithelium has been rightfully regarded as a potential source of odontogenic tumours and cysts, but, without substantial evidence. Also, whether the basal cell layer retains within it, some properties of ectomesenchyme, which was imbibed during the early embryogenesis and hence its neuroectodermal relation, is not known. Here, an attempt is made to establish the hidden neuroectodermal potential of the oral epithelium, especially the basal layer, by observing the expression of known neuroectodermal markers, NSE (Neuron Specific Enolase), Synaptophysin and CD99. The expression of the same markers has also been studied in Ameloblastoma, connecting it with oral epithelium, in turn establishing basal cell layer as a potential source of Ameloblastoma.