Open AccessHaemophagocytic Lymphohistiocytosis with Lung Cavity and Lytic Bone Lesion in A 45 Day Infant
Author(s) -
Sanjay Natu,
Ujjwala Keskar,
Manas Kumar Behera,
Sambhaji C Chate
Publication year - 2014
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2014/6521.4145
Subject(s) - lytic cycle , hemophagocytic lymphohistiocytosis , lesion , histiocytosis , lung , medicine , immune system , langerhans cell histiocytosis , pathology , immunology , disease , virus
Haemophagocytic lymphohistiocytosis (HLH) is a potentially fatal, hyper inflammatory condition which is caused by a highly stimulated but ineffective immune response. We are presenting here, a case of HLH which occurred in a 45 day infant. Presence of lung cavity and a lytic bone lesion in the skull, as was seen in this case, have not been reported in HLH in the literature. This raises a possibility of a simultaneous occurrence of HLH and Langerhans cell histiocytosis. In a child who presents with septicaemia but does not respond to treatment, the possibility of HLH needs to be considered.