Open AccessSerum hsCRP: A Novel Marker for Prediction of Cerebrovascular Accidents (Stroke)
Author(s) -
Dibyaratna Patgiri,
Mauchumi Saikia Pathak,
Pradeep Sharma,
Tridip Kutum,
Nirmali Mattack
Publication year - 2014
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2014/10386.5302
Subject(s) - medicine , stroke (engine) , diabetes mellitus , hyperlipidemia , atrial fibrillation , risk factor , pediatrics , emergency medicine , cardiology , engineering , mechanical engineering , endocrinology
Strokes are caused by disruption of the blood supply to the brain. This may result from either blockage or rupture of a blood vessel. Yearly 15 million people worldwide suffer a stroke. India ranks second worldwide in terms of deaths from stroke. The incidence of stroke increases with age affecting the economically productive middle aged population. Hypertension and male sex are other risk factors for stroke. C-Reactive Protein (CRP) is an acute phase protein whose concentration rises in blood following inflammation. Formerly, assays for CRP detected its rise only after significant inflammation. However, recently developed high sensitivity assays (hsCRP) enable the measurement of CRP in individuals who are apparently healthy. Several studies indicate that hsCRP is elevated in individuals who are at risk of developing Coronary Artery Disease or Cerebrovascular events, the elevation may be found years before the first detection of vascular problems. In the absence of other biochemical markers, the present study aimed to evaluate the predictive and diagnostic role of hsCRP in stroke.