Open AccessExpression of Inducible Nitric Oxide Synthase in Keratocystic Odontogenic Tumour and Variants of Ameloblastoma – A Comparative Study
Author(s) -
H Diana,
Ruth Maya,
Sadhishkumar Balakrishnan,
Sanjana Murali,
Maya Ramesh
Publication year - 2014
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2014/10288.5201
Subject(s) - ameloblastoma , keratocyst , pathology , nitric oxide synthase , immunohistochemistry , medicine , keratocystic odontogenic tumor , dentigerous cyst , odontogenic , dentistry , nitric oxide , maxilla
The odontogenic keratocyst (OKC) is a histopathologiocally and behaviourally unique and specific entity. It is the most aggressive and recurrent of all the cysts and shows characteristics resembling both cyst and a tumour. The unique nature of OKC and the recent shift of OKC as a tumour made us evaluate yet another factor, Inducible nitric oxide synthase an (iNos) enzyme which has been implicated in the tumourigenesis of various neoplasms. Aims and Objects: The objective of the study was to analyse and compare the immunohistochemical expression of iNOS in odontogenic keratocysts (OKC's) in variants of ameloblastoma affecting the oral cavity, to determine the neoplastic potential of OKC and to reinforce the classification of OKC as keratocystic odontogenic tumour.