Open AccessMolecular Docking Study for Inhibitors of Aggregatibacter actinomycetamcomitans Toxins in Treatment of Aggressive Perioodontitis
Author(s) -
Raj L S M,
P S Krishna
Publication year - 2014
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2014/10067.5133
Subject(s) - aggregatibacter actinomycetemcomitans , docking (animal) , aggressive periodontitis , virulence , protein data bank (rcsb pdb) , virtual screening , cytolethal distending toxin , microbiology and biotechnology , virulence factor , periodontitis , chemistry , toxin , biology , drug discovery , microbial toxins , biochemistry , bacteria , gene , medicine , genetics , nursing , porphyromonas gingivalis
Periodontitis is a chronic inflammatory disease of the periodontal tissues causing periodontal attachment loss and destruction of the alveolar bone which leads to mobility and loss of teeth. Aggregatibacter actinomycetemcomitans (Aa) is a gram negative, capnophilic, coccobacillus that plays an important role in aggressive Periodontitis. Aa produces a variety of virulence factors that facilitate the colonization, invasion and destruction of the periodontal tissues. Leukotoxin and cytolethal distending toxin (Cdt) are most important virulence factors of Aa.