Open AccessApolipoprotein E Gene Polymorphism And Its Effect On Plasma Lipids In Arteriosclerosis
Author(s) -
Prakash D Zende,
Mangesh P Bankar,
Pramod Kamble,
Abdulrahaman A. Momin
Publication year - 2013
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2013/6195.3455
Subject(s) - medicine , arteriosclerosis , endocrinology , allele , apolipoprotein e , apolipoprotein b , genotype , cholesterol , triglyceride , blood lipids , biology , gene polymorphism , myocardial infarction , lipoprotein , disease , gene , genetics
Myocardial infarction and stroke are leading causes of death worldwide. Primarily, arteriosclerosis is responsible for these events. There is a strong family history suggesting a genetic cause. Apolipoprotein E (apo E) plays an important role in lipid metabolism. Apo E is polymorphic with three isoforms, ApoE2, ApoE3 and ApoE4; which translate into three alleles of the gene. Its polymorphism may be a risk determinant of atherosclerosis.