Open AccessEffect of High Dose of Steroid on Plateletcount in Acute Stage of Dengue Fever with Thrombocytopenia
Author(s) -
Shashidhara Kc,
Murthy Ka,
Gowdappa Hb,
A Bhograj
Publication year - 2013
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2013/6135.3143
Subject(s) - dengue fever , medicine , platelet , dexamethasone , gastroenterology , immunology
Dengue infection is the most rapidly spreading mosquito-borne viral disease in the world and an estimated 50 million dengue infections reported annually. The pathogenesis of Thrombocytopenia in dengue fever (DF) is not clearly understood. Increased peripheral destruction of antibody coated platelets and acute bone marrow suppression were strongly suspected as the possible mechanism. This often leads to life threatening dengue hemorrhagic fever (DHF) and Dengue shock syndrome (DSS). Steroids are used in the treatment of Idiopathic thrombocytopenic purpura to increase the platelet count which is mediated by auto antibodies .This hypothesis would support the use of steroids in dengue fever.