Open AccessThe Role of ‘Paraoxonase-1 Activity’ as an Antioxidant in Coronary Artery Diseases
Author(s) -
Maharudra Shekhanawar,
Sarala M Shekhanawar,
D Krisnaswamy,
V Indumati,
D Satishkumar,
Vikrant Vijay,
Thiyagarajan Rajeshwari,
M Amareshwar
Publication year - 2013
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2013/5144.3118
Subject(s) - pon1 , paraoxonase , coronary artery disease , medicine , aryldialkylphosphatase , antioxidant , triglyceride , cholesterol , lipid profile , endocrinology , lipoprotein , high density lipoprotein , cardiology , oxidative stress , biology , biochemistry , gene , genotype
A majority of the Coronary Artery Diseases (CAD) result from complications of atherosclerosis. There is a growing body of evidence which has revealed that the reduced activity of the HDL-associated enzyme, paraoxonase1 (PON1), is predictive of vascular disease in humans, which include the results from prospective studies. The mechanisms by which PON1 activity influences risk of vascular disease continue to be evaluated. It is generally thought that PON1 contributes to the antioxidant, and thus, to the antiatherogenic properties of High Density Lipoproteins (HDL). Depleted antioxidant levels could be a risk factor for coronary artery disease. Hence, this study was done to evaluate PON1, as antioxidant, in CAD patients.