Open AccessFetal Haemoglobin and β -globin Gene Cluster Haplotypes among Sickle Cell Patients in Chhattisgarh
Author(s) -
Sanjana Bhagat,
Pradeep Kumar Patra,
A. K. Thakur
Publication year - 2013
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2013/4381.2744
Subject(s) - haplotype , sickle cell trait , sickle cell anemia , fetal hemoglobin , restriction fragment length polymorphism , globin , biology , disease , genetics , genotype , immunology , medicine , gene , cell , pregnancy , fetus
Foetal Haemoglobin (HbF) is the best-known genetic modulator of sickle cell anaemia, which varies dramatically in concentration in the blood of these patients. The patients with SCA display a remarkable variability in the disease severity. High HbF levels and the β-globin gene cluster haplotypes influence the clinical presentation of sickle cell disease. To identify the genetic modifiers which influence the disease severity, we conducted a β-globin haplotype analysis in the sickle cell disease patients of Chhattisgarh.