Open AccessCan Vitamin B-Complex Aggravate the Carbamazepine Induced Toxic Epidermal Necrolysis?
Author(s) -
Mayuresh Fegade,
Sushama A. Bhounsule,
Ian A Pereira
Publication year - 2012
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2012/4744.2566
Subject(s) - toxic epidermal necrolysis , carbamazepine , medicine , erythema multiforme , dermatology , mucocutaneous zone , rash , exfoliative dermatitis , erythema , erythroderma , antibiotics , disease , epilepsy , psychiatry , microbiology and biotechnology , biology
Toxic Epidermal Necrolysis (TEN), which is also known as Lyell's syndrome, is a widespread, life-threatening, mucocutaneous disease that is particularly observed secondary to drugtaking and less commonly secondary to infections and immunization. Carbamazepine is associated with benign pruritic rash in 10-15% of the patients, but the life threatening dermatological syndromes like exfoliative dermatitis, erythema multiforme, the Stevens-Johnson Syndrome (SJS) and TEN are rarely seen with the carbamazepine treatment. The 32 year old female suffering from chronic backache, who was prescribed carbamazepine along with an intravenous combination of vitamin B-complex and calcium, developed fever, cough and mucocutaneous manifestations of TEN after 15 days of the treatment. She was treated in the hospital with systemic steroids, intravenous immunoglobulins, antibiotics, intravenous fluids and supportive care. In spite of the above treatment, the patient could not survive for more than seven days.