Lymphoepithelial Carcinoma: A Case of a Rare Parotid Gland Tumor | Zendy

Christopher G. Tang | Zendy; Thomas M. Schmidtknecht | Zendy; Grace Y. Tang | Zendy; Luke J. Schloegel | Zendy; Barry M. Rasgon | Zendy

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Lymphoepithelial Carcinoma: A Case of a Rare Parotid Gland Tumor

Author(s) -

Christopher G. Tang,

Thomas M. Schmidtknecht,

Grace Y. Tang,

Luke J. Schloegel,

Barry M. Rasgon

Publication year - 2012

Publication title -

the permanente journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.445

H-Index - 30

eISSN - 1552-5775

pISSN - 1552-5767

DOI - 10.7812/tpp/12.963

Subject(s) - medicine , parotid gland , neck dissection , cytokeratin , pathology , salivary gland , cervical lymphadenopathy , carcinoma , parotidectomy , immunohistochemistry , disease

A 29-year-old woman presented from another hospital with a 10-month history of an enlarging left-sided facial mass. Computed tomographic scan revealed a mass in the superficial lobe of the left parotid gland with left-sided cervical lymphadenopathy. The patient received a total left parotidectomy and a selective neck dissection. Histopathologic slides revealed lymphoepithelial carcinoma (LEC) that stained positive for cytokeratin, as well as Epstein-Barr virus (EBV). An LEC of the parotid is a rare salivary gland tumor accounting for less than 1% of all salivary gland tumors. As reaffirmed in our case, LEC is more common in women, occurs primarily in the parotid gland, and has an ethnic predilection. Histologic analysis reveals an infiltrative, poorly differentiated tumor nestled in a lymphoid stroma, with near 100% positivity for EBV in endemic areas. Complete resection of this poorly differentiated carcinoma followed by postoperative radiation is essential for local control.

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