Open AccessEvaluation of precipitation time of the aluminum salts adsorbed potentially frozen vaccines used in the Polish National Immunization Schedule for their pre-qualification before the administration
Author(s) -
Paulina Górska,
Małgorzata Główka,
Katarzyna Woźnica,
Aleksandra Anna Zasada
Publication year - 2022
Publication title -
clinical and experimental vaccine research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.958
H-Index - 11
eISSN - 2287-366X
pISSN - 2287-3651
DOI - 10.7774/cevr.2022.11.2.155
Subject(s) - medicine , cold chain , immunization , precipitation , vaccination , schedule , virology , immunology , antigen , chemistry , computer science , meteorology , operating system , physics , food science
Vaccines adsorbed on aluminum adjuvants irreversibly lose potency after freezing and their safety is affected. To prevent the administration of such vaccines, the World Health Organization developed the Shake Test designed to determine whether adsorbed vaccines have been frozen or not. However, the Shake Test is difficult and time-consuming when routinely conducted at the place of vaccination. In this study, a modified shake test for prequalification of potentially frozen vaccines was elaborated.