Open AccessSeverity of adverse reactions is associated with T-cell response in mRNA-1273 vaccinated health care workers
Author(s) -
Hanna Klingel,
Maike Lauen,
Alex Krüttgen,
Matthias Imöhl,
Michael Kleines
Publication year - 2022
Publication title -
clinical and experimental vaccine research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.958
H-Index - 11
eISSN - 2287-366X
pISSN - 2287-3651
DOI - 10.7774/cevr.2022.11.1.121
Subject(s) - immunogenicity , medicine , reactogenicity , antibody response , immunology , vaccination , messenger rna , adverse effect , immunization , t cell , antibody , immune system , gene , biology , biochemistry
Knowledge about mRNA-1273 elicited T-cell response is limited. We investigated adverse reactions and interferon gamma release by specific T-cells among mRNA-1273 vaccinated health care workers. Seven to 13 weeks after complete vaccination low levels of specific T-cells were detected not correlating with antibody response. Severity of symptoms after first and number of symptoms after second immunization were associated with T-cell response. Assessment of T-cell response in addition to antibody response is crucial because even few specific T-cells could add to protection against infection. Investigation of mRNA-1273 induced inflammatory processes might help improve reactogenicity and immunogenicity.