Open AccessOlive Leaf Extract Supplementation Combined with Calorie-Restricted Diet on Reducing Body Weight and Fat Mass in Obese Women: Result of a Randomized Control Trial
Author(s) -
Fatemeh Haidari,
Forough Shayesteh,
Majid Mohammadshahi,
Mohammad Taha Jalali,
Kambiz Ahmadi Angali
Publication year - 2021
Publication title -
clinical nutrition research
Language(s) - English
Resource type - Journals
eISSN - 2287-3740
pISSN - 2287-3732
DOI - 10.7762/cnr.2021.10.4.314
Subject(s) - medicine , body mass index , adiponectin , weight loss , insulin resistance , obesity , endocrinology , placebo , randomized controlled trial , waist , lipid profile , adipokine , high density lipoprotein , cholesterol , alternative medicine , pathology
The present trial aims to evaluate a supplementation of the olive leaf extract (OLE) in adjunct with a weight loss diet on anthropometric indices, glycemic indices, lipid profile, as well as the level of adipokines, and free fatty acid in obese women. We carried out an 8-week randomized, placebo-controlled, double-blind, parallel-group, clinical trial. The participants were randomly stratified according to age and they were assigned to one of the two study groups: Standard weight loss diet (estimated daily energy requirements minus 500 kcal) + OLE supplementation (n = 35) in intervention group or Standard weight loss diet (estimated daily energy requirements minus 500 kcal) + placebo (n = 35) in placebo group. The study groups were homogeneous regarding the baseline age, height, weight, body mass index (BMI), waist circumferences, married status, and physical activity levels (p > 0.05). The results of analysis of covariance presented significant decreases in BMI, fat mass, and body weight in the OLE group compared to those in the placebo group (p < 0.05). At the end of the study, the serum levels of fasting blood sugar, insulin, low-density lipoprotein cholesterol, total cholesterol, leptin, fatty free acid, and homeostasis model assessment-insulin resistance significantly decreased, and serum levels of high-density lipoprotein cholesterol and adiponectin elevated in the intervention group (p < 0.05). Based on results it seems that the addition of OLE to a hypocaloric diet for 8-week compared with a hypocaloric diet alone may be more effective in modifying obesity and metabolic risk factors.