Open AccessAssociation between Inflammatory Biomarkers and Nutritional Status in Fatty Liver
Author(s) -
HeeSook Lim,
Joungyun Choi,
Bo Ra Lee,
Sang Gyune Kim,
Young Seok Kim,
JeongJu Yoo
Publication year - 2020
Publication title -
clinical nutrition research
Language(s) - English
Resource type - Journals
eISSN - 2287-3740
pISSN - 2287-3732
DOI - 10.7762/cnr.2020.9.3.182
Subject(s) - adiponectin , medicine , fatty liver , vitamin e , adipokine , vitamin c , gastroenterology , body mass index , vitamin , endocrinology , obesity , antioxidant , disease , insulin resistance , biology , biochemistry
The prevalence and progression of non-alcoholic fatty liver disease (NAFLD) is mediated via several factors correlating with hepatic necroinflammation (adipokines/cytokines). This study was performed to analyze the level of inflammatory markers according to the presence of NAFLD and to identify related nutritional factors. A total of 80 adults were classified into 2 groups (healthy and NAFLD), and their body composition, blood tests, and eating habits were evaluated. In addition, inflammatory markers (adiponectin, high-sensitivity C-reactive protein [CRP], and tumor necrosis factor-alpha [TNF-α]), nutrient intake status, and dietary quality were compared. The quality of diet was assessed according to the nutrient adequacy ratio and the mean adequacy ratio (MAR). The NAFLD group had a higher body mass index (p < 0.001) than the healthy group and also carried significantly higher CRP levels (p < 0.001) but lower adiponectin (p = 0.001). TNF-α levels increased significantly with fatty liver grade (p = 0.023). The NAFLD group showed significantly higher intake of energy, carbohydrates, iron, sodium, vitamin A and saturated fatty acids, but significantly lower intake of zinc and vitamin E than the healthy group. The MAR values were slightly higher in the NAFLD group but without any significant difference. The levels of adiponectin and vitamin E showed a significant inverse correlation (p < 0.05). Nutritional management of NAFLD patients is important, and the intake of antioxidant and anti-inflammatory nutrients such as zinc and vitamin E should be emphasized.