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Background  Coronary artery disease (CAD) and depression cause great burden to society and frequently co-occur. The exact mechanisms of this comorbidity are unclear. FK506-binding protein 51 (FKBP51) is correlated with cardiovascular disease and depression. The aim of this study was to determine the role of the seven single nucleotide polymorphisms (SNPs) of  FKBP5  that code FKBP51, namely,  rs1360780  (C>T),  rs2817032  (T>C),  rs2817035  (G>A),  rs9296158  (G>A),  rs9470079  (G>A),  rs4713902  (T>C), and  rs3800373  (C>T) in a patient’s susceptibility to comorbid CAD and depression.    Methods  We enrolled 271 Northern Chinese Han patients with CAD, including 123 patients with depression and 147 patients without depression. We also included 113 healthy controls that match the patients’ sex and age. Genomic DNA from whole blood was extracted, and seven SNPs were assessed using MassArray method. Patient Health Questionnaire-9 was applied to access the depression.    Results  The GA genotype for  rs9470079  was associated with a significantly decreased risk of CAD (odds ratio = 0.506, 95% confidence interval = 0.316–0.810,  P  = 0.005) when the GG genotype was used as reference. A statistically significant difference was observed among females but not among males in the  rs9470079  genotype and allele frequency. Patients with CAD were further divided into CAD+D and CAD-D groups according to the presence of comorbid depression and were compared with the controls. Significant differences were found regarding the genotype and allele frequency of  rs2817035  and  rs9470079  in CAD+H groups compared with the control subjects in all groups and the female groups ( P  < 0.05).    Conclusions  The current study found a remarkable association between  FKBP5  gene variations and the risk of comorbid CAD and depression in a north Chinese population.  rs9470079  may be a potential gene locus for the incidence of comorbid CAD and depression.

Association of FKBP5 polymorphisms with patient susceptibility to coronary artery disease comorbid with depression