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Acinetobacter baumannii , an important emerging pathogen of nosocomial infections, is known for its ability to form biofilms. Biofilm formation increases the survival rate of  A. baumannii  on dry surfaces and may contribute to its persistence in the hospital environment, which increases the probability of nosocomial infections and outbreaks. This study was undertaken to characterize the biofilm production of different strains of  A. baumannii  and the effects of chemical compounds, especially antibiotics, on biofilm formation. In this study, no statistically significant relationship was observed between the ability to form a biofilm and the antimicrobial susceptibility of the  A. baumannii  clinical isolates. Biofilm formation caused by  A. baumannii  ATCC 17978 after gene knockout of two-component regulatory system gene  baeR , efflux pump genes  emrA/emrB  and outer membrane coding gene  ompA  revealed that all mutant strains had less biofilm formation than the wild-type strain, which was further supported by the images from scanning electron microscopy and confocal laser scanning microscopy. The addition of amikacin, colistin, LL-37 or tannic acid decreased the biofilm formation ability of  A. baumannii . In contrast, the addition of lower subinhibitory concentration tigecycline increased the biofilm formation ability of  A. baumannii . Minimum biofilm eradication concentrations of amikacin, imipenem, colistin, and tigecycline were increased obviously for both wild type and multidrug resistant clinical strain  A. baumannii  VGH2. In conclusion, the biofilm formation ability of  A. baumannii  varied in different strains, involved many genes and could be influenced by many chemical compounds.

peerj

Characterization of biofilm production in different strains of <i>Acinetobacter baumannii</i> and the effects of chemical compounds on biofilm formation

Characterization of biofilm production in different strains of Acinetobacter baumannii and the effects of chemical compounds on biofilm formation