English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Trauma and related fear exert significant influence on mental and physical health throughout the lifespan and are associated with intergenerational patterns of development, health, and behavior. DNA methylation and gene expression are involved in our developmental adaptations to our experiences and can be influenced by social interventions. Patterns of DNA methylation and expression of a gene involved in neurodevelopment and psychiatric risk ( BDNF ) have been linked with childhood trauma. Given the intergenerational patterns of health and behavior, and previous links between childhood trauma and  BDNF  methylation and expression, this study investigated the potential for maternal history of traumatic experiences to influence development in her newborn, via changes in her newborn’s  BDNF  methylation and expression. We found that mothers’ trauma history was associated with epigenetic regulation of  BDNF  in their newborns. Moreover, the association between maternal trauma and  BDNF  methylation and expression patterns were moderated by newborn sex. Male newborns showed increased  BDNF  expression with maternal exposure to child abuse ( p  = .001), and increased  BDNF  methylation with greater maternal fear ( p  = .001). Female newborns showed reduced  BDNF  expression with greater maternal fear ( p  = .004). Practitioners strive to identify prevention and intervention avenues that will reduce the harmful effects of trauma. Future research should consider the potential for maternal historical trauma experiences to influence offspring DNA methylation and gene expression in a manner that could alter development and inform novel prevention strategies.

Maternal trauma and fear history predictBDNFmethylation and gene expression in newborns