Open AccessPreclinical models of acute liver failure: a comprehensive review
Author(s) -
Joshua Hefler,
Braulio A. MarfilGarza,
Rena Pawlick,
Darren H. Freed,
Constantine Karvellas,
David Bigam,
A.M. James Shapiro
Publication year - 2021
Publication title -
peerj
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.927
H-Index - 70
ISSN - 2167-8359
DOI - 10.7717/peerj.12579
Subject(s) - medicine , liver failure , intensive care medicine , disease , liver disease , pathophysiology , bioinformatics , biology
Acute liver failure is marked by the rapid deterioration of liver function in a previously well patient over period of days to weeks. Though relatively rare, it is associated with high morbidity and mortality. This makes it a challenging disease to study clinically, necessitating reliance on preclinical models as means to explore pathophysiology and novel therapies. Preclinical models of acute liver failure are artificial by nature, and generally fall into one of three categories: surgical, pharmacologic or immunogenic. This article reviews preclinical models of acute liver failure and considers their relevance in modeling clinical disease.