Open AccessRun for your life: can exercise be used to effectively target GLUT4 in diabetic cardiac disease?
Author(s) -
Peter Bowman,
Godfrey L. Smith,
Gwyn W. Gould
Publication year - 2021
Publication title -
peerj
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.927
H-Index - 70
ISSN - 2167-8359
DOI - 10.7717/peerj.11485
Subject(s) - medicine , disease , glut4 , diabetes mellitus , diabetic cardiomyopathy , population , intensive care medicine , cause of death , cardiomyopathy , insulin resistance , environmental health , endocrinology , heart failure
The global incidence, associated mortality rates and economic burden of diabetes are now such that it is considered one of the most pressing worldwide public health challenges. Considerable research is now devoted to better understanding the mechanisms underlying the onset and progression of this disease, with an ultimate aim of improving the array of available preventive and therapeutic interventions. One area of particular unmet clinical need is the significantly elevated rate of cardiomyopathy in diabetic patients, which in part contributes to cardiovascular disease being the primary cause of premature death in this population. This review will first consider the role of metabolism and more specifically the insulin sensitive glucose transporter GLUT4 in diabetic cardiac disease, before addressing how we may use exercise to intervene in order to beneficially impact key functional clinical outcomes.