Open AccessAnti-inflammatory and antiaging properties of chlorogenic acid on UV-induced fibroblast cell
Author(s) -
Ermi Girsang,
Chrismis N. Ginting,
I Nyoman Ehrich Lister,
Kamila Yashfa Gunawan,
Wahyu Widowati
Publication year - 2021
Publication title -
peerj
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.927
H-Index - 70
ISSN - 2167-8359
DOI - 10.7717/peerj.11419
Subject(s) - oxidative stress , reactive oxygen species , fibroblast , apoptosis , inflammation , dermal fibroblast , tumor necrosis factor alpha , chlorogenic acid , microbiology and biotechnology , chemistry , gene expression , antioxidant , cell , biology , immunology , biochemistry , gene , in vitro , food science
Background Skin aging is the most common dermatological problem caused by intrinsic and extrinsic factor, such as exposure to (ultraviolet) UV rays. Chlorogenic acid (CA) is a phenolic compound which is known for its antioxidant properties against oxidative stress. Objective This study investigates the antiaging and anti-inflammatory properties of CA on UV-induced skin fibroblast cells. Methods Anti-inflammatory properties of CA were assessed by measuring inflammatory-related proteins IL-1β and TNF-α, while antiaging properties of CA were assessed by measuring reactive oxygen species (ROS), apoptosis, live and necrotic cells, and COL-3 gene expression level. Results Treating UV-induced skin fibroblast cells with CA decreased the level of ROS, IL-1β, TNF-α, apoptotic cells, and necrotic cells and increased live cells and COL-3 gene expression. Conclusion CA has the potential as the protective compound against inflammation and aging by decreasing the level ROS, pro-inflammatory cytokines IL-1β and TNF-α, apoptotic cells, and necrotic cells and by increasing live cells and COL-3 gene expression.
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