Open AccessAssociation between Dietary Inflammatory Index and Type 2 diabetes mellitus in Xinjiang Uyghur autonomous region, China
Author(s) -
Wenhui Fu,
Hualian Pei,
Nitin Shivappa,
James R. Hébert,
Tao Luo,
Tian Tian,
Dilibaier Alimu,
Zewen Zhang,
Jianghong Dai
Publication year - 2021
Publication title -
peerj
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.927
H-Index - 70
ISSN - 2167-8359
DOI - 10.7717/peerj.11159
Subject(s) - medicine , odds ratio , type 2 diabetes mellitus , logistic regression , confounding , confidence interval , demography , diabetes mellitus , type 2 diabetes , cohort study , population , cohort , body mass index , environmental health , endocrinology , sociology
Background Diet and inflammation have both been studied in relation to type 2 diabetes mellitus (T2DM). The aim of this cross-sectional study was to examine the association between the Dietary Inflammatory Index (DII®) and T2DM. Methods Subjects were adults enrolled in the baseline study of the Xinjiang multi-ethnic natural population cohort and health follow-up study from January to May 2019. The study involved 5,105 subjects (58.7% men) between 35 and 74 years of age. The DII score was calculated from a data obtained via a food frequency questionnaire consisting of 127 food items. Results Logistic regression analyses were used to estimate the odds ratios (ORs) and 95% confidence intervals (95% CIs) of DII in relation to T2DM. After adjusting for potential confounders, compared to subjects in the 1st DII quintile, subjects in the 5th quintile (i.e., with the most pro-inflammatory diet) had higher odds of T2DM (OR = 3.27, 95%CI:2.38,4.50; p < 0.001). Conclusions Our results suggest that a pro-inflammatory diet is associated with a higher risk of T2DM in this population of Chinese adults.