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The  p53  activation is induced by stressors, such as DNA damage, oxidative stress, and activated oncogenes, and can promote cell cycle arrest, cellular senescence, and apoptosis. The large yellow croaker ( Larimichthys crocea ) is an important warm temperate marine fish in the Chinese aquiculture industry. However, few studies have investigated the role of  p53  in the response of  L .  crocea  to environmental stressors. Therefore, the aim of the present study was to assess the spatiotemporal mRNA expression levels of genes involved in the  p53  signaling pathway of the large yellow croaker in response to cold stress. The results showed significant changes in the expression levels of  p53 ,  p21 ,  MDM2 ,  IGF-1 ,  Gadd45 ,   Fas , and  Akt  in various tissues of the large yellow croaker in response to cold stress for different times. As compared to the control group,  p53  mRNA expression was upregulated in most of the examined tissues at 24 h with the exception of the gill. In the liver ,  the expression levels of  p53  and  Fas  were significantly decreased at 12 h, while those of  p21 ,  MDM2 ,  IGF-1 ,  Gadd45  were dramatically increased.  Akt  expression was notably changed in response to cold in several tissues. These results suggested that  p53  was potentially a key gene in the large yellow croaker response to cold and possibly other environmental stressors.

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The p53 signaling pathway of the large yellow croaker (Larimichthys crocea) responds to acute cold stress: evidence via spatiotemporal expression analysis of p53, p21, MDM2, IGF-1, Gadd45, Fas, and Akt