Open AccessPredicción de sensibilidad a la warfarina basada en VKORC1 y CYP2C9 en pacientes de diferentes lugares de Colombia
Author(s) -
Ricardo Cifuentes,
Juan Murillo-Rojas,
Esperanza Avella-Vargas
Publication year - 2015
Publication title -
biomédica/biomedica
Language(s) - Spanish
Resource type - Journals
eISSN - 2590-7379
pISSN - 0120-4157
DOI - 10.7705/biomedica.v36i1.2795
Subject(s) - vkorc1 , warfarin , cyp2c9 , pharmacogenetics , medicine , genotype , polymorphism (computer science) , population , biology , genetics , atrial fibrillation , environmental health , cytochrome p450 , metabolism , gene
In the search to prevent hemorrhages associated with anticoagulant therapy, a major goal is to validate predictors of sensitivity to warfarin. However, previous studies in Colombia that included polymorphisms in the VKORC1 and CYP2C9 genes as predictors reported different algorithm performances to explain dose variations, and did not evaluate the prediction of sensitivity to warfarin.