Open AccessDisagreement between PCR and serological diagnosis of Trypanosoma cruzi infection in blood donors from a Colombian endemic region
Author(s) -
Liliana Torcoroma García Sánchez,
Jhancy Rocío Aguilar Jiménez,
Marly Yojhana Bueno,
Érika Marcela Moreno,
Herminia Ramírez,
Nelson Daza
Publication year - 2021
Publication title -
biomédica/biomedica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.26
H-Index - 28
eISSN - 2590-7379
pISSN - 0120-4157
DOI - 10.7705/biomedica.5441
Subject(s) - serology , chagas disease , trypanosoma cruzi , parasitemia , asymptomatic , medicine , polymerase chain reaction , virology , antibody , immunology , biology , parasite hosting , malaria , genetics , gene , plasmodium falciparum , world wide web , computer science
Chagas' disease is the leading cause of infectious myocarditis worldwide. This infection caused by Trypanosoma cruzi is usually life-long and asymptomatic; however, the third part of infected people can develop severe or even fatal cardiomyopathy. As the parasitemia in the chronic phase is both low-grade and intermittent, T. cruzi infection is principally detected by serology, although this method has sensitivity and specificity limitations.