Open AccessAcquired immunity and Alzheimer's disease
Author(s) -
Weixi Feng,
Yanli Zhang,
Peng Sun,
Ming Xiao
Publication year - 2023
Publication title -
journal of biomedical research/journal of biomedical research
Language(s) - English
Resource type - Journals
eISSN - 2352-4685
pISSN - 1674-8301
DOI - 10.7555/jbr.36.20220083
Subject(s) - microglia , glymphatic system , immune system , neuroscience , disease , pathogenesis , immunology , immunity , antibody , biology , lymphatic system , medicine , inflammation , pathology , cerebrospinal fluid
Alzheimer's disease (AD) is an age-related neurodegenerative disease characterized by progressive cognitive defects. The role of the central immune system dominated by microglia in the progression of AD has been extensively investigated. However, little is known about the peripheral immune system in AD pathogenesis. Recently, with the discovery of the meningeal lymphatic vessels and glymphatic system, the roles of the acquired immunity in the maintenance of central homeostasis and neurodegenerative diseases have attracted an increasing attention. The T cells not only regulate the function of neurons, astrocytes, microglia, oligodendrocytes and brain microvascular endothelial cells, but also participate in the clearance of β-amyloid (Aβ) plaques. Apart from producing antibodies to bind Aβ peptides, the B cells affect Aβ-related cascades via a variety of antibody-independent mechanisms. This review systemically summarizes the recent progress in understanding pathophysiological roles of the T cells and B cells in AD.