Open AccessEffect of Non-surgical Periodontal Treatment on Lipoxin A4 Levels in Periodontitis Patients
Author(s) -
Emrah Türkmen,
Ceren Gökmenoğlu,
Cankat Kara,
Figen Öngöz Dede,
Huriye Erbak Yılmaz,
Varol Çanakçı
Publication year - 2022
Publication title -
dokladi na bʺlgarskata akademiâ na naukite
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.244
H-Index - 17
eISSN - 2367-5535
pISSN - 1310-1331
DOI - 10.7546/crabs.2022.02.15
Subject(s) - saliva , medicine , periodontitis , chronic periodontitis , gastroenterology , pathogenesis , dentistry , significant difference , aggressive periodontitis
The aim of this study was to determine the lipoxin A4 (LXA4) in gingival crevicular fluid (GCF) and saliva in chronic periodontitis (CP) patients before and after non-surgical periodontal treatment (NSPT). A total of twenty subjects, ten patients with CP and ten healthy individuals were included in this study. Clinical measurements, GCF and saliva samples were obtained at the beginning and one month after NSPT. GCF and salivary LXA4 were investigated by ELISA. Salivary LXA4 were significantly higher in CP than in healthy subjects (p 0.05). GCF LXA4 were lower in CP and decreased after NSPT, but these differences were not significant (p > 0.05). However, GCF LXA4 in post-treatment CP group were significantly lower than in healthy subjects (p < 0.05). Negative correlation was found between probing depth and GCF LXA4 in CP group (r = −0.717; p < 0.05). Within the limitations of this study, LXA4 might have a potential role in both the pathogenesis of periodontitis and the healing process.