Open AccessThe study of EGFR transport in single cell using an automatic method of trajectory identification
Author(s) -
H Li,
ZW Duan,
Shi Xue Dou,
Wang Py
Publication year - 2012
Publication title -
wuli xuebao
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.199
H-Index - 47
ISSN - 1000-3290
DOI - 10.7498/aps.61.068701
Subject(s) - trajectory , brownian motion , identification (biology) , motion (physics) , displacement (psychology) , diffusion , mean squared displacement , computer science , square (algebra) , epidermal growth factor receptor , biological system , physics , receptor , mathematics , chemistry , artificial intelligence , biology , geometry , molecular dynamics , psychology , botany , quantum mechanics , astronomy , psychotherapist , thermodynamics , biochemistry
We study the characteristics of motion modes of epidermal growth factor receptor (EGFR) trafficking in single cell, by using the automatic method of trajectory identification which is based on the directional persistence and mean square displacement analysis. Each trajectory of EGFRs is divided into four modes of motion: directional motion, super-diffusion, Brownian motion and sub-diffusion. The corresponding dynamic parameters of different modes of motion are calculated and discussed, providing an insight into intracellular trafficking of receptors.