Open AccessThe spatio-temporal stochastic resonance of calcium in coupled hepatocytes systems affected by subthreshold stimuli and noise
Author(s) -
Wang Bao-Hua,
Qishao Lu,
Lü Shu-Juan
Publication year - 2009
Publication title -
wuli xuebao
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.199
H-Index - 47
ISSN - 1000-3290
DOI - 10.7498/aps.58.7458
Subject(s) - subthreshold conduction , stochastic resonance , noise (video) , resonance (particle physics) , physics , coupling (piping) , autocorrelation , biological system , materials science , molecular physics , statistical physics , acoustics , nuclear magnetic resonance , computer science , mathematics , atomic physics , quantum mechanics , biology , transistor , voltage , artificial intelligence , metallurgy , image (mathematics) , statistics
The influence of subthreshold periodic stimuli on temporal-spatial resonance of Ca2+ in a stochastic coupled hepatocytes system is studied. When the frequency of stimuli is close to that of the determinate coupled system before the Hopf bifurcation, the eruption rate of Ca2+ is enhanced greatly in the stochastic system. By computing the autocorrelation function of the eruption rate, it is found that the temporal resonance of Ca2+ becomes more ordered by the subthreshold stimuli. Furthermore, for a given coupling strength between cells, there is an optimal noise level to make the Ca2+ resonance reach maximum, and the optimal noise level also increases with the coupling strength increasing. Though the action of subthreshold stimuli promotes the temporal resonance of the system, it strengthens the sensibility to noise and then depresses the spatial ordered calcium waves induced by medium-strength noise only, as shown by the analysis by the spatial Fourier transform and its structure function.