Open AccessPhotoacoustic angiography for mouse brain cortex using near-infrared light
Author(s) -
Sihua Yang,
Guolu Yin
Publication year - 2009
Publication title -
wuli xuebao
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.199
H-Index - 47
ISSN - 1000-3290
DOI - 10.7498/aps.58.4760
Subject(s) - indocyanine green , photoacoustic imaging in biomedicine , materials science , optics , photoacoustic effect , photoacoustic doppler effect , biomedical engineering , angiography , neuroimaging , brain cortex , infrared , light scattering , medicine , scattering , radiology , physics , psychiatry
Photoacoustic imaging is a novel noninvasive imaging technique of biological tissue that overcomes the overwhelming scattering of light in biological tissue by utilizing ultrasonic wave to translate the image signal. In this study, near-infrared light and indocyanine green as an optical contrast agent were used to achieve the cerebrovascular distribution by photoacoustic imaging. Near-infrared light penetrates deep into the brain tissues through the skin and skull, and the indocyanine green enhances the photoacoustic signals of the blood vessels. A photoacoustic angiography of vascular distribution in the mouse brain in vivo was acquired that matches the anatomical photograph well. The experimental result demonstrates the photoacoustic imaging with near-infrared light and optical contrast agent has the potential for functional and molecular biomedical imaging.