Open AccessNeuron excitability changes induced by low-power laser irradiation
Author(s) -
Qiao Xiao-yan,
Gang Li,
Yumin Dong,
Bin He
Publication year - 2008
Publication title -
wuli xuebao
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.199
H-Index - 47
ISSN - 1000-3290
DOI - 10.7498/aps.57.1259
Subject(s) - depolarization , neuron , biophysics , patch clamp , irradiation , membrane potential , electrophysiology , materials science , neuroscience , physics , biology , nuclear physics
The change in excitability induced by low-power laser was investigated for freshly dissociated rat hippocampal CA3 pyramidal neuron using the whole-cell patch clamp technique. The experimental results indicate that the activation potential of Na+ channel shifted towards a more negative potential, the peak amplitude of INa increased in a voltage-dependent and reversible manner, the steady-state activation curve and inactivation curve of INa were significantly shifted, the half-activation voltage and the half-inactivation voltage respectively changed from (-4414±528)mV to (-5655±614)mV(n=8,Pn=8, P+ channel, further affect the depolarizing and firing of action potential, and finally be involved in adjusting the excitability of neurons.