Micro-dynamics of Ca2+ signals in single heart cells | Zendy

Yongqiang Bai | Zendy; AiHui Tang | Zendy; ShiQiang Wang | Zendy; Xing Zhu | Zendy

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Micro-dynamics of Ca2+ signals in single heart cells

Author(s) -

Yongqiang Bai,

AiHui Tang,

ShiQiang Wang,

Xing Zhu

Publication year - 2007

Publication title -

acta physica sinica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.199

H-Index - 47

ISSN - 1000-3290

DOI - 10.7498/aps.56.3607

Subject(s) - microscope , total internal reflection fluorescence microscope , reflection (computer programming) , dynamics (music) , signal (programming language) , field (mathematics) , physics , optics , stochastic resonance , transformation (genetics) , noise (video) , fluorescence , acoustics , computer science , chemistry , artificial intelligence , image (mathematics) , pure mathematics , programming language , biochemistry , gene , mathematics

We used a total internal reflection fluorescence microscope based on the near field optics principle to study the Ca2+ signals in single heart cells of Sprague-Dawley rat. Due to the high signal to noise ratio and high speed of data acquisition of this microscope, the Ca2+ images show complex 2-dimensional wave patterns. The local elementary Ca2+ release units play important role in the formation and transformation of Ca2+ wave. Simulations based on Fire-Diffuse-Fire model show that the Ca2+ wave, composed of Ca2+ release units, may steadily exist in single heart cell. Our results will be helpful for understanding the micro-dynamics of living excitable medium.

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