Open AccessThe theoretical study of the effects of salt on structure transition of B-DNA to Z-DNA
Author(s) -
Dong Rui Xin,
Xi Yan
Publication year - 2004
Publication title -
wuli xuebao
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.199
H-Index - 47
ISSN - 1000-3290
DOI - 10.7498/aps.53.4414
Subject(s) - stacking , hydrogen bond , salt (chemistry) , z dna , dna , crystallography , torsion (gastropod) , materials science , thermodynamics , chemical physics , chemistry , physics , molecule , nuclear magnetic resonance , quantum mechanics , biochemistry , biology , zoology
On the basis of our previous elastic model which is related to the salt ion conc entration, we put forth a new model of B-DNA to Z-DNA transition by considerin g interactions of the hydrogen-bond and base-stacking in Z-DNA, and discuss the effects of salt concentration on the structure transition of B-Z and obtain the force extension curves, the probability distribution curve of the folding angle and the critical torque of B-Z transition at various salt concentrations. The results show that Z-DNA appears when salt concentration reaches 2.4mol/L,and the probability of Z-form begins to increase and the torsion of B-Z trans ition decreases with the increase of salt concentration.